Coach Tony's lecture focuses on the critical balance between speed and endurance for quarter-mile runners. He emphasizes the need to tailor training regimens to individual athletes' capacities, using workouts like the "2020" drill to gradually build both speed and roaming capacity. By prioritizing speed development alongside technical competency, Coach Tony illustrates how speed positively impacts endurance, leading to enhanced performance in the 400 meters. Through strategic training methods that minimize neuro-muscular fatigue while maximizing muscular fatigue, he provides insights into optimizing athletes' speed-endurance capabilities for peak performance on the track.