Reference - Pro Spread Full Playbook formation and plays section. 

Working with your top personnel groupings, identify a few top formations per grouping that you like and can run a core run play that should be very difficult for defenses to stop. 

As you do this, start listing core plays with each formation/grouping with complimentary plays in mind. Example: I Right 24 Power, I Right 25 Counter, I Right Waggle Pass. Here you have the base run, a complimentary run and a play action pass. They all work together.